COMMON SOURCES: parsley, celery, celeriac, and chamomile tea
PURPORTED HEALTH BENEFITS: Is said to lower CD38 levels in
mitochondria, thereby preventing NAD+ from being depleted. It has been
observed that NAD+ levels tend to go down with age and that CD38 levels go
up. Mouse studies have shown that apigenin lowers CD38 levels and as a
result NAD+ levels do not attenuate.
PLANT COMPOUND TYPE: flavone
DESCRIPTION: NAD+ declines with age and one way people try to fix this
issue is through supplementation with NAD+ precursors such as NMN and NR.
Another strategy is to reduce CD38 through ingestion of apigenin or quercetin.
Both strategies can be used at the same time and there is some evidence that
this is beneficial to human health, but on the other hand it's very new stuff
and none of this is fully verified.
The Therapeutic Potential of Apigenin
Salehi, Venditti, Sharifi-Rad, Kregiel, etc.
QUOTE: "Several plant bioactive compounds have exhibited functional activities
that suggest they could play a remarkable role in preventing a wide range of
chronic diseases. The largest group of naturally-occurring polyphenols are the
flavonoids, including apigenin."
QUOTE: "Among the wide variety of phenolic compounds, apigenin is one of the
most renowned, with countless nutritional and organoleptic characteristics.
Nonetheless and more interestingly, it can also contribute with its beneficial
health properties, which could lead to a possible inclusion in nutraceutical
QUOTE: "A high number of studies carried out over the years have indicated that
apigenin has many interesting pharmacological activities and nutraceutical potential.
As an example, its properties as an antioxidant are well known, and it can also be a
therapeutic agent to overcome diseases like inflammation, autoimmune, neurodegenerative
disease, and even several types of cancers."
NAD+ metabolism in aging & 3 strategies to rejuvenate
The Sheekey Science Show
Three strategies to increase NAD+: MAKE, BREAK, or TAKE strategies. 1)
Ingest prescursor molecules (NR, NMN), 2) Ingest CD38
inhibitors such as epigenin or luteolinidin, 3) Activate enzymes involved in
NAD+ biosynthesis such as NAMPT.