COMMON SOURCES: blueberries, almonds, grape leaves
PURPORTED HEALTH BENEFITS:
PLANT COMPOUND TYPE: stilbenoid / polyphenol
STRUCTURE:
DESCRIPTION: Pterostilbene is an antioxidant that's supposed to be really good for you, especially when used with
Nicotinamide Riboside, but who cares about all that. Just remember that the P is silent!
But seriously, pterostilbene is very similar to resveratrol, but it has much
greater bioavailability, which basically means that the body can more
readily absorb and use it.
Pterostilbene is a polyphenol, a type of molecule that occurs in plants,
particularly small berries and nuts.
Pterostilbenes connection to sirtuins is just one of the reasons scientists are so
excited by the compound.
Pterostilbene and resveratrol have very similar chemical structures.
However, there are differences and pterostilbene's structure makes it more
bioavailable than resveratrol.
A randomized, double-blind, placebo-controlled of healthy human subjects given
pterostilbene for 6-8 weeks, showed pterostilbene to be safe for human use at dosages up to 250 mg per day.
Pterostilbene differs from resveratrol by exhibiting increased bioavailability (80% compared
to 20% in resveratrol) due to the presence of two methoxy groups which cause it to exhibit
increased lipophilic and oral absorption.
Sirtuins are protein enzymes that regulate numerous cellular functions,
including aging, inflammation, detoxification, stress resistance, fat and
glucose metabolism, circadian rhythms, and mitochondrial biogenesis.
In humans and other mammals there are seven different sirtuins (SIRT-1 through SIRT-7)
that are involved with different functions and are either directly or indirectly related to
longevity.
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